Life Science
Biotechnology
Aeras Global TB Vaccine Foundation, Cell Culture Suite and Powder Vaccine Facility, Rockville, MD
Middough has managed a number of assignments for the Aeras Global TB Vaccine Foundation including the design of a new cell culture suite and a Powder Vaccine Clinical Launch Facility.
The cell culture and harvest suite is an expansion of existing clean manufacturing space, located adjacent to protein purification. The new BSL-2 facility will utilize both stainless steel and disposable 300L cell culture bioreactors and harvesting equipment including a continuous centrifuge. Seed and media preparation space is also included within the suite.
The Powder Vaccine Facility will support new products in development by Aeras. The process utilizes spray drying technology and is designed to produce five million doses of vaccine packaged for clinical trials and subsequent product launch. The 25,000 SF facility will be designed to be LEED® certified.
International Centre for Infectious Diseases, Winnipeg, Canada
Middough provided preliminary engineering services for the International Centre for Infectious Diseases (ICID) 130,000 SF, $88 million, cGMP clinical production facility for HIV/AIDS vaccines, located in Winnipeg, Manitoba. This integrated facility is designed to support and accelerate process development and clinical trials for a large number of highly promising candidate vaccines, following laboratory-based discovery and screening.
Middough's scope of services included process architecture layouts, process flow diagrams, equipment selection and a cost estimate. Process operations included microbial fermentation, cell culture with viral vectors and egg-based recombinant technologies, as well as separation and purification and aseptic filling. The facility is designed to BSL-3/2 criteria.
Cargill, Texturing, Germantown, WI
Cargill sought out Middough to provide detailed process and facility engineering services for expanding its fermentation based production facility. The scope included an addition of a second processing line and second packaging line including new control system, controlled area production building expansion, warehouse freezer expansion, new employee locker rooms and associated utility additions.
As part of the design effort, Middough's Process architecture team performed studies to improve people and material flow at the facility. Results from the survey were incorporated into the final design.